A Meta-analysis of Ostial and Trunk versus Distal Lesions in Unprotected Left Main Coronary Artery Stenting.

Aims: To assess outcomes for percutaneous coronary intervention (PCI) in ostial and trunk versus distal unprotected left main coronary artery (LMCA) lesions in the drugeluted stent (DES) era. Study Design: A meta-analysis and systematic review. Methods: With the help of a librarian, we searched Medline, Embase, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, and the Clinical Trials Registry from 2001 to July 2012. We included studies that enrolled ≥ 50 patients and had ≥6 months of follow-up. Our co-primary endpoints were the incidence of major adverse cardiac events (MACE) and target lesion/vessel revascularization (TLR/TVR). Data was abstracted and analyzed by two independent reviewers and differences were resolved by consensus. We assessed the results for heterogeneity in our analysis by examining the forest plots and then calculating a Q statistic, which we compared with the I2 index. If there was no evidence of statistical heterogeneity and pooling of results was clinically appropriate, a combined estimate was obtained using the fixed-effects model; otherwise the random-effects model was used. Results: We identified 11studies involving 3,718 patients. Mean duration of follow-up was 29 months (range 12-62months). Compared with ostial and trunk stenting, distal LMCA PCI was associated with increased MACE (OR 1.95, 95% CI 1.43-2.66) and TLR/TVR (OR 3.13, 95% CI 1.90-5.16).No significant differences were detected for cardiac death (OR 1.06, 95% CI 0.72-1.58, p=0.58), MI (OR 1.15, 95% CI 0.74-1.77, p=0.80) or stent thrombosis (OR 1.57, 95% CI 0.90-2.77, p=0.41). Conclusion: Patients with ostial and trunk LMCA lesions treated with DES have better outcomes than patients with distal lesions. Our findings may support unprotected nondistal LMCA stenting as a primary approach in selected patient subsets.

Substance use among medical students: time to reignite the debate?

BACKGROUND: Substance use among medical students could impact on the conduct, safety and efficiency of future doctors. Despite serious medicolegal, ethical and political ramifications, there is little research on the subject, especially from the Indian subcontinent. We aimed to explore the patterns of substance use among a sample of medical students from the Indian subcontinent. METHODS: An opportunistic, cross-sectional survey of medical students from 76 medical schools attending an inter-medical school festival. A brief self-reported questionnaire was used to identify current and lifetime use of tobacco, alcohol, cannabis, heroin and non-prescription drugs. Multivariable logistic regression analysis was used to identify factors associated with illicit substance use. RESULTS: Responses from 2135 medical students were analysed. Current alcohol and tobacco (chewable or smoked) use was reported by 7.1% and 6.1% of the respondents, respectively. Lifetime use of illicit substances was reported by 143 (6.7%) respondents. Use of illicit substances was strongly associated with use of tobacco, alcohol and non-prescription drugs. CONCLUSION: This study provides a snapshot of the problem of substance use among medical students from the Indian subcontinent. The reported prevalence of alcohol and illicit substance use in our sample was lower, while tobacco use was similar, when compared with data from western studies. Further research is needed from the Indian subcontinent to study nationwide patterns of substance use among medical students, and to identify important determinants and reinforce protective factors. Strategies need to be developed for supporting students with a substance use problem.